Nicholas N. Shaw

Department/Affiliation: Chemistry, Organic
Phone: 330-287-1945
Office Address: 103 Severance Hall
Email: nshaw@wooster.edu

Degrees

• B.A., Chemistry, St. Olaf College, 2002
• Ph.D., Organic Chemistry, Clemson University, 2010

Area of Research

• Design and synthesis of therapeutic compounds
• The form and function of nucleic acids
• Targeting DNA:RNA hybrid structures
• Teaching chemistry at the undergraduate level
  

Courses Taught

• Chemistry 110: Introductory Chemistry
• Chemistry 120: Principles of Chemistry
• Chemistry 211: Organic Chemistry I
• Chemistry 212: Organic Chemistry II

Awards & Professional Memberships

• American Chemical Society

Publications

• “Aminoglycoside Binding to A-form DNA.” Xi, Hongjuan; Shaw, Nicholas N.; Skriba, Michael; Arya, Dev P. Manuscript in preparation.
• "Molecular Recognition of a DNA:RNA Hybrid: Sub-nanomolar Binding by a Neomycin-Methidium Conjugate." Shaw, Nicholas N.; Xi, Hongjuan.; Arya, Dev P. Bioorg. Med. Chem. Lett. 2008, 18(14), 4142-4145.
• "Recognition of the Unique Structure of DNA:RNA Hybrids." Shaw, Nicholas N.; Arya, Dev P. Biochimie 2008, 90(7), 1026-1039.
• “Novel Targets for Aminoglycosides.” In Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery. Ed. Arya, Dev P. New Jersey: John Wiley and Sons, 2007. 289-314.
• “Neomycin improves cationic lipid-mediated transfection of DNA in human cells”. Napoli, S.; Carbone, G.M.; Catapano, C.; Shaw, N.; Arya, D.P.; Bioorg. Med.Chem.Lett. 2005, 15, 3467–3469.