Mark J. Snider
Robert E. Wilson Associate Professor of Chemistry, Chair of Chemistry
Department/Affiliation: Chemistry, BCMB
Office Address: 201 Severance
- B.A. Capital University, Chemistry 1997
- Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001
Area of Research
- Mechanistic and structural enzymology of aerobic nicotinic acid (Vitamin B3) catabolism in Bordetella species.
- Determining the genes and mechanisms of degradation of antidepressants by bacteria in the environment.
- Functional characterization of novel phosphagen kinases, with the goal of discerning the evolution of substrate specificity, cooperative substrate binding and quaternary structure.
- CHEM 101: Chemistry and the World in Which We Live
- CHEM 111: Introductory Chemistry
- CHEM 112: Principles of Chemistry
- CHEM 399: Biophysical Chemistry
- BCMB 303: Techniques in Biochemistry & Molecular Biology
- BCMB 331: Principles of Biochemistry
- BCMB 332: Biochemistry of Metabolism
- BCMB 401: Introduction to Independent Study
- IDPT 101: First Year Seminars in Critical Inquiry
I.S. Projects Mentored
- Matthew Henke: Developing a mechanistic proposal for 2,5-dihydroxypyridine-5,6-dioxygenase (NicX) from Bordetella bronchiseptica.
- Matthew Bauerle: Structure-function analysis of 6-hydroxynicotinate 3-monooxygenase (NicC).
- Jonathan Fox: Isolation of bacterial strains in wastewater sludge capable of degradation of sertraline, venlafaxine and triclorcarban.
External Grants Awarded
- Research Corporation for Science Advancement: Multi-Investigator Cottrell College Science Award Program (2012-2014), "Bacterial Degradation of Pharmaceuticals and Personal Care Products During Waste Water Treatment" with Stephanie Strand (Biology) and Melissa Schultz (Chemistry).
- National Science Foundation (2008-2011), "Acquisition of an LC/MS/MS to Enhance Undergraduate Research and Teaching" with Melissa Schultz and Paul Edmiston (Chemistry).
- National Science Foundation (2006-2009), "Acquisition of an Isothermal Titration Calorimeter" with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
- National Science Foundation (2004-2007), "RUI: Comparative Structure – Function Analysis of Phosphagen Kinases" with Paul Edmiston and Dean Fraga (Biology).
- 2012-13 with W. W. Cleland in the Department of Biochemistry, University of Wisconsin-Madison, and with David Ballou in the Department of Biological Chemistry, University of Michigan.
- 2007-08 with Tadhg Begley in the Department of Chemical Biology, Cornell University.
Recent Publications (* denotes Wooster Undergraduate)
- A. Palmer*, B. Begress*, J. Van Houten*, M. J. Snider, and D. Fraga (2013) Characterization of a putative oomycete taurocyamine kinase: Implications for the evolution of the phosphagen kinase family. Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology, 166; 173-181.
- G. K. Schroeder, L. Zhou, M. J. Snider, X. Chen, and R. Wolfenden (2012) Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry 51, 6476-6486.
- J. Bragg, A. Rajkovic*, C. Anderson, R. Curtis, J. V-Houten*, B. Bergres*, C. Naples*, M. Snider, D. Fraga, and M. Singer (2012) Identification and characterization of an arginine kinase from Myxococcus xanthus required from fruiting body formation and cell differentiation; J. Bacteriology 194, 2668-2676.
- V. A. Kincaid*, E. D. Sullivan*, R. D. Klein*, J. W. Noel*, R. S. Rowlett, M. J. Snider (2012) Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme maleamate amidohydrolase from BrodetellaBronchiseptica RB50;Biochemistry 51, 545-554.
- A. Hazra, M. J. Snider, A. Chatterjee, D. Chatterjee, J. W. Hanes, D. G. Hilmey, K. Krishnamoorthy, K. M. Mccullock, S. O'Leary, J. M. Sanders, M. J. Waitner, and T. P. Begley (2009) Coenzyme and prosthetic group biosynthesis; Encyclopedia of Microbiology; Moselio Schaechter, Ed.; Vol. 5, 79-88, Oxford: Elsevier.