Independent Minds, Working Together
Mark J. Snider

Mark J. Snider

Robert E. Wilson Associate Professor of Chemistry, Chair of Chemistry

Department/Affiliation: Chemistry, BCMB
Phone: 330-263-2391
Office Address: 201 Severance
Email

Curriculum Vitae

Degrees

  • B.A. Capital University, Chemistry 1997
  • Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001

Area of Research

  • Mechanistic and structural enzymology of aerobic nicotinic acid (Vitamin B3) catabolism in Bordetella species.
  • Determining the genes and mechanisms of degradation of antidepressants by bacteria in the environment.
  • Functional characterization of novel phosphagen kinases, with the goal of discerning the evolution of substrate specificity, cooperative substrate binding and quaternary structure.

Courses Taught

  • CHEM 101: Chemistry and the World in Which We Live
  • CHEM 110: Introductory Chemistry
  • CHEM 120: Principles of Chemistry
  • CHEM 399: Biophysical Chemistry
  • BCMB 303: Techniques in Biochemistry & Molecular Biology
  • BCMB 331: Principles of Biochemistry
  • BCMB 332: Biochemistry of Metabolism
  • BCMB 401: Introduction to Independent Study
  • IDPT 101: First Year Seminars in Critical Inquiry

I.S. Projects Mentored

  • Matthew Henke: Developing a mechanistic proposal for 2,5-dihydroxypyridine-5,6-dioxygenase (NicX) from Bordetella bronchiseptica.
  • Matthew Bauerle: Structure-function analysis of 6-hydroxynicotinate 3-monooxygenase (NicC).
  • Jonathan Fox: Isolation of bacterial strains in wastewater sludge capable of degradation of sertraline, venlafaxine and triclorcarban.

External Grants Awarded

  • Research Corporation for Science Advancement: Multi-Investigator Cottrell College Science Award Program (2012-2014), "Bacterial Degradation of Pharmaceuticals and Personal Care Products During Waste Water Treatment" with Stephanie Strand (Biology) and Melissa Schultz (Chemistry).
  • National Science Foundation (2008-2011), "Acquisition of an LC/MS/MS to Enhance Undergraduate Research and Teaching" with Melissa Schultz and Paul Edmiston (Chemistry).
  • National Science Foundation (2006-2009), "Acquisition of an Isothermal Titration Calorimeter" with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
  • National Science Foundation (2004-2007), "RUI: Comparative Structure – Function Analysis of Phosphagen Kinases" with Paul Edmiston and Dean Fraga (Biology).

Research Leaves

  • 2012-13 with W. W. Cleland in the Department of Biochemistry, University of Wisconsin-Madison, and with David Ballou in the Department of Biological Chemistry, University of Michigan.
  • 2007-08 with Tadhg Begley in the Department of Chemical Biology, Cornell University.

Recent Publications (* denotes Wooster Undergraduate)

  • G. K. Schroeder, L. Zhou, M. J. Snider, X. Chen, and R. Wolfenden (2012) Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry 51, 6476-6486.
  • J. Bragg, A. Rajkovic*, C. Anderson, R. Curtis, J. V-Houten*, B. Bergres*, C. Naples*, M. Snider, D. Fraga, and M. Singer (2012) Identification and characterization of an arginine kinase from Myxococcus xanthus required from fruiting body formation and cell differentiation; J. Bacteriology 194, 2668-2676.
  • V. A. Kincaid*, E. D. Sullivan*, R. D. Klein*, J. W. Noel*, R. S. Rowlett, M. J. Snider (2012) Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme maleamate amidohydrolase from BrodetellaBronchiseptica RB50;Biochemistry 51, 545-554.
  • A. Hazra, M. J. Snider, A. Chatterjee, D. Chatterjee, J. W. Hanes, D. G. Hilmey, K. Krishnamoorthy, K. M. Mccullock, S. O'Leary, J. M. Sanders, M. J. Waitner, and T. P. Begley (2009) Coenzyme and prosthetic group biosynthesis; Encyclopedia of Microbiology; Moselio Schaechter, Ed.; Vol. 5, 79-88, Oxford: Elsevier.
  • L. D. Andrews*, J. Graham*, M. J. Snider, D. Fraga. (2008) Characterization of a novel bacterial arginine kinase from Desulfotelea psychrophilia - Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology150: 312-319.
  • M. J. Jourden*, C. N. Clarke*, A. K. Palmer*, E. J. Barth*, R. C. Prada*, R. N. Hale*, D. Fraga, M. J. Snider, P. L. Edmiston (2007) Changing the substrate specificity of creatine kinase from creatine to glycocyamine: evidence for a highly evolved active site. Biochimica et Biophysica Acta - Proteins and Proteomics 1774: 1519-1527.
  • M. J. Jourden, M. J. Thomenius, P. R. Geiss, L. A. Horst, M. M. Barty, G. B. Mulligan, R. M. Almeida, B. A. Kersteen, N. R. Myers, M. J. Snider, C. L. Borders, Jr., P. L. Edmiston (2005) Transition state stabilization by six arginines clustered in the active site of creatine kinase. Biochimica et Biophysica Acta - Proteins and Proteomics 1751: 178-183.
  • C. H. Borchers, V. E. Marquez, G. K. Gottfried, S. E. Short, M. J. Snider, P. Speir and R. Wolfenden (2004) Fourier transform ion cyclotron resonance mass spectrometry reveals the presence of a water molecule in an enzyme-transition state analogue complex. Proceedings of the National Academy of Sciences - USA 101: 15341-15345.
  • M. Snider, B. Temple and R. Wolfenden (2004) The path to the transition state in enzyme reactions: a survey of catalytic efficiencies. Journal of Physical Organic Chemistry 17: 586-591.
  • R. Wolfenden and M. J. Snider (2001) The Depth of Chemical Time and the Power of Enzymes as Catalysts. Accounts of Chemical Research 34, 938-945.