Mark J. Snider
Robert E. Wilson Professor of Chemistry, Biochemistry
Department/Affiliation: Chemistry, BCMB
Office Address: 201 Severance
Curriculum Vitae (CV)
- B.A. Capital University, Chemistry 1997
- Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001
Area of Research
- Mechanistic and structural enzymology of aerobic nicotinic acid (Vitamin B3) catabolism
in Bordetella species.
- Determining the genes and mechanisms of degradation of antidepressants by bacteria
in the environment.
- Functional characterization of novel phosphagen kinases, with the goal of discerning
the evolution of substrate specificity, cooperative substrate binding and quaternary
- CHEM 101: Chemistry and the World in Which We Live
- CHEM 111: Introductory Chemistry
- CHEM 112: Principles of Chemistry
- CHEM 399: Biophysical Chemistry
- BCMB 303: Techniques in Biochemistry & Molecular Biology
- BCMB 331: Principles of Biochemistry
- BCMB 332: Biochemistry of Metabolism
- BCMB 401: Introduction to Independent Study
- IDPT 101: First Year Seminars in Critical Inquiry
I.S. Projects Mentored
- Matthew Henke: Developing a mechanistic proposal for 2,5-dihydroxypyridine-5,6-dioxygenase
(NicX) from Bordetella bronchiseptica.
- Matthew Bauerle: Structure-function analysis of 6-hydroxynicotinate 3-monooxygenase
- Jonathan Fox: Isolation of bacterial strains in wastewater sludge capable of degradation
of sertraline, venlafaxine and triclorcarban.
External Grants Awarded
- Research Corporation for Science Advancement: Multi-Investigator Cottrell College
Science Award Program (2012-2014), "Bacterial Degradation of Pharmaceuticals and Personal
Care Products During Waste Water Treatment" with Stephanie Strand (Biology) and Melissa
- National Science Foundation (2008-2011), "Acquisition of an LC/MS/MS to Enhance Undergraduate
Research and Teaching" with Melissa Schultz and Paul Edmiston (Chemistry).
- National Science Foundation (2006-2009), "Acquisition of an Isothermal Titration Calorimeter"
with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
- National Science Foundation (2004-2007), "RUI: Comparative Structure – Function Analysis
of Phosphagen Kinases" with Paul Edmiston and Dean Fraga (Biology).
- 2012-13 with W. W. Cleland in the Department of Biochemistry, University of Wisconsin-Madison,
and with David Ballou in the Department of Biological Chemistry, University of Michigan.
- 2007-08 with Tadhg Begley in the Department of Chemical Biology, Cornell University.
Recent Publications (* denotes Wooster Undergraduate)
- Katherine A. Hicks, Meigan E. Yuen, Wei Feng Zhen, Tyler J. Gerwig*, Ryan W. Story*,
Megan Kopp, Mark J. Snider (2016) Structural and biochemical characterization of
6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved
in aerobic nicotinate degradation. Biochemistry 55, 3432-3446.
- D. Fraga, M. Aryal*, J. E. Hall*, E. Rae*, and M. Snider (2015) Characterization
of the arginine kinase isoforms in Caenorhabditis elegans. Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology
- Z. H. Harvey* and M. J. Snider (2014) Draft genome of the nicotinate-metablizing
soil bacterium Bacillus niacini (DSM 2923). Genome Announc. 2 (6) e01251-14.
- A. Palmer*, B. Begress*, J. Van Houten*, M. J. Snider, and D. Fraga (2013) Characterization
of a putative oomycete taurocyamine kinase: Implications for the evolution of the
phosphagen kinase family. Comparative Physiology and Biochemistry; Part B: Biochemistry
& Molecular Biology, 166; 173-181.
- G. K. Schroeder, L. Zhou, M. J. Snider, X. Chen, and R. Wolfenden (2012) Flight of
a cytidine deaminase complex with an imperfect transition state analogue inhibitor:
mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry
- J. Bragg, A. Rajkovic*, C. Anderson, R. Curtis, J. V-Houten*, B. Bergres*, C. Naples*,
M. Snider, D. Fraga, and M. Singer (2012) Identification and characterization of an
arginine kinase from Myxococcus xanthus required from fruiting body formation and
cell differentiation; J. Bacteriology 194, 2668-2676.
- V. A. Kincaid*, E. D. Sullivan*, R. D. Klein*, J. W. Noel*, R. S. Rowlett, M. J. Snider
(2012) Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme
maleamate amidohydrolase from BrodetellaBronchiseptica RB50;Biochemistry 51, 545-554.