Mark J. Snider

Mark J. Snider

Robert E. Wilson Professor of Chemistry, Biochemistry

Department/Affiliation: Chemistry, BCMB
Phone: 330-263-2391
Office Address: 201 Severance
Curriculum Vitae (CV)


  • B.A. Capital University, Chemistry 1997
  • Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001

Area of Research

  • Mechanistic and structural enzymology of aerobic nicotinic acid (Vitamin B3) catabolism in Bordetella species.
  • Determining the genes and mechanisms of degradation of antidepressants by bacteria in the environment.
  • Functional characterization of novel phosphagen kinases, with the goal of discerning the evolution of substrate specificity, cooperative substrate binding and quaternary structure.

Courses Taught

  • CHEM 101: Chemistry and the World in Which We Live
  • CHEM 111: Introductory Chemistry
  • CHEM 112: Principles of Chemistry
  • CHEM 399: Biophysical Chemistry
  • BCMB 303: Techniques in Biochemistry & Molecular Biology
  • BCMB 331: Principles of Biochemistry
  • BCMB 332: Biochemistry of Metabolism
  • BCMB 401: Introduction to Independent Study
  • IDPT 101: First Year Seminars in Critical Inquiry

I.S. Projects Mentored

  • Matthew Henke: Developing a mechanistic proposal for 2,5-dihydroxypyridine-5,6-dioxygenase (NicX) from Bordetella bronchiseptica.
  • Matthew Bauerle: Structure-function analysis of 6-hydroxynicotinate 3-monooxygenase (NicC).
  • Jonathan Fox: Isolation of bacterial strains in wastewater sludge capable of degradation of sertraline, venlafaxine and triclorcarban.

External Grants Awarded

  • Research Corporation for Science Advancement: Multi-Investigator Cottrell College Science Award Program (2012-2014), "Bacterial Degradation of Pharmaceuticals and Personal Care Products During Waste Water Treatment" with Stephanie Strand (Biology) and Melissa Schultz (Chemistry).
  • National Science Foundation (2008-2011), "Acquisition of an LC/MS/MS to Enhance Undergraduate Research and Teaching" with Melissa Schultz and Paul Edmiston (Chemistry).
  • National Science Foundation (2006-2009), "Acquisition of an Isothermal Titration Calorimeter" with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
  • National Science Foundation (2004-2007), "RUI: Comparative Structure – Function Analysis of Phosphagen Kinases" with Paul Edmiston and Dean Fraga (Biology).

Research Leaves

  • 2012-13 with W. W. Cleland in the Department of Biochemistry, University of Wisconsin-Madison, and with David Ballou in the Department of Biological Chemistry, University of Michigan.
  • 2007-08 with Tadhg Begley in the Department of Chemical Biology, Cornell University.

Recent Publications (* denotes Wooster Undergraduate)

  • Katherine A. Hicks, Meigan E. Yuen, Wei Feng Zhen, Tyler J. Gerwig*, Ryan W. Story*, Megan Kopp, Mark J. Snider (2016)  Structural and biochemical characterization of 6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved in aerobic nicotinate degradation. Biochemistry 55, 3432-3446.
  • D. Fraga, M. Aryal*, J. E. Hall*, E. Rae*, and M. Snider (2015)  Characterization of the arginine kinase isoforms in Caenorhabditis elegans.  Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology 187; 85-101.
  • Z. H. Harvey* and M. J. Snider (2014)  Draft genome of the nicotinate-metablizing soil bacterium Bacillus niacini (DSM 2923).  Genome Announc. 2 (6) e01251-14.
  • A. Palmer*, B. Begress*, J. Van Houten*, M. J. Snider, and D. Fraga (2013) Characterization of a putative oomycete taurocyamine kinase: Implications for the evolution of the phosphagen kinase family. Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology, 166; 173-181.
  • G. K. Schroeder, L. Zhou, M. J. Snider, X. Chen, and R. Wolfenden (2012) Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry 51, 6476-6486.
  • J. Bragg, A. Rajkovic*, C. Anderson, R. Curtis, J. V-Houten*, B. Bergres*, C. Naples*, M. Snider, D. Fraga, and M. Singer (2012) Identification and characterization of an arginine kinase from Myxococcus xanthus required from fruiting body formation and cell differentiation; J. Bacteriology 194, 2668-2676.
  • V. A. Kincaid*, E. D. Sullivan*, R. D. Klein*, J. W. Noel*, R. S. Rowlett, M. J. Snider (2012) Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme maleamate amidohydrolase from BrodetellaBronchiseptica RB50;Biochemistry 51, 545-554.