Dr. K. Domike - Research Interests

 

My research interests lie within the realms of Biological Physics and Materials Science. Recently, my interests have been primary in the realm of protein agglomeration mechanisms. My work has focused on quantifying the aggregation mechanisms and kinetics of large-scale protein aggregates, using a model protein, in an effort to understand the relationship to aggregation found in brain disease.

 

Independent Study Research Students

2009

Evan Heidtmann (Physics and Math double major) - General research area: Physical and Mathematical Modeling of Protein Aggregation

Mike Zappitello (Physics and Math double major) - General research area: Physical and Mathematical Modeling of Protein Aggregation

 

Previous and currently submitted publications include:

M.R.H. Krebs, K. Domike, A.M. Donald, "Protein Aggregation - More than just Fibrils" to be published in Biochemical Transations, 2009.

K. Domike, A.M. Donald, "Kinetics of Spherulite Formation and Growth: Salt and Protein Concentration Dependence on Proteins Beta-lactoglobulin and Insulin," accepted to the International Journal of Biological Macromolecules, 2009.

K. Domike, E. Hardin, D. Armstead, A.M. Donald, "Investigating the Inner Structure of Irregular Beta-lactoglobulin Spherulites," submitted to the European Physical Journal E, 2008 (REU summer research collaboration)

M.R.H. Krebs, K.Domike, D. Cannon, A.M. Donald, "Common Motifs in Protein Self-Assembly," Faraday Discussions, 139, 2008

K. Domike, A.M. Donald, "Thermal Dependence of Thermally Induced Protein Spherulite Formation and Growth: Kinetics of Beta-lactoglobulin and Insulin," Biomacromolecules, 2007, vol. 8, num. 12, pp. 3930-3937

Pending publications include:

K. Domike, Y. Bai, "Characterization and Visualization of Plasticizer on the Surface of Poly(vinyl chloride) Based Endotracheal Tubes," preparing for submission to the Journal of Biomedical Materials.

K. Domike, V. Pacheco-Fowler, Y. Bai, J. Goss, "Epithelial Cell Growth on Surface Modified Poly(vinyl chloride) Endotracheal Tubes," preparing for submission.