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  • Chapter 19

    • Reactions of Amines

      • 1.  Reaction as a proton base

      • 2.  Alkylation

      • 3.  Acylation to form amides

      • 4.  Reaction with sulfonyl chlorides to give sulfonamides

      • 5.  Diazotization*

        • a.  Reactions of diazonium salts*

          • i.  Hydrolysis

          • ii.  The Sandermeyer reaction

          • iii.  Replacement by flouride or iodide

          • iv.  Reduction to hydrogen

          • v.  Diazo coupling

    • Synthesis of Amines

      • 1.  Reductive amination ADDS 1 R Group*

        • a.  Primary amines

        • b.  Secondary amines

        • c.  Tertiary amines

      • 2.  Acylation-reduction of amines ADDS 1 Alkyl group

      • 3.  Alkylation of ammonia

      • 4.  Reduction of azides ADDS NH3

      • 5.  Reduction of nitriles ADDS CH2NH2

      • 6.  Reduction of nitro compounds

      • Example of multistep synthesis

      • Summary of Diazotization