Ph.D. University of North Carolina at Chapel Hill, Biochemistry & Biophysics 2001
Areas of Research
Mechanistic and structural enzymology of aerobic nicotinic acid (Vitamin B3) catabolism.
Determining the genes and mechanisms of degradation of antidepressants by bacteria
in the environment.
Functional characterization of novel phosphagen kinases, with the goal of discerning
the evolution of substrate specificity, cooperative substrate binding and quaternary
CHEM 101: Chemistry and the World in Which We Live
CHEM 111: General Chemistry I
CHEM 112: General Chemistry II
CHEM 399: Biophysical Chemistry
BCMB 303: Techniques in Biochemistry & Molecular Biology
BCMB 331: Principles of Biochemistry
BCMB 332: Biochemistry of Metabolism
BCMB 401: Introduction to Independent Study
IDPT 101: First Year Seminars in Critical Inquiry
I.S. Projects Mentored
Laura Sherer: Biophysical characterization of the cofactors in the putative NicAB
complex from Bacillus niacini.
Tsun Ki Jerrick To: Characterizing the genetic determinants of the nicotinic acid
degradation pathway in Bacillus niacini.
Manish Aryal: Evolution of negative cooperativity in phosphagen kinases
External Grants Awarded
National Science Foundation (2018-present), Molecular Biophysics Program RUI: Collaborative Research: Enzymology of Bacterial Nicotinic Acid Catabolism by Mark Snider (PI), Katherine Hicks (PI, SUNY Cortland) $ 551,536.
National Science Foundation (2016-2019), Major Research Instrumentation Program Acquisition
of an NMR Spectrometer to Sustain Excellence in Undergraduate Research with Paul Bonvallet
(PI), Judith Amburgey-Peters, Spring Knapp and Sarah Sobeck
Research Corporation for Science Advancement: Multi-Investigator Cottrell College
Science Award Program (2012-2014), "Bacterial Degradation of Pharmaceuticals and Personal
Care Products During Waste Water Treatment" with Stephanie Strand (Biology) and Melissa
National Science Foundation (2008-2011), "Acquisition of an LC/MS/MS to Enhance Undergraduate
Research and Teaching" with Melissa Schultz and Paul Edmiston (Chemistry).
National Science Foundation (2006-2009), "Acquisition of an Isothermal Titration Calorimeter"
with Paul Bonvallet (Chemistry) and Don Jacobs (Physics).
National Science Foundation (2004-2007), "RUI: Comparative Structure – Function Analysis
of Phosphagen Kinases" with Paul Edmiston and Dean Fraga (Biology).
2018 – 2019: at The College of Wooster; Transient state kinetic analysis of the mechanism
of 6-hydroxynicotinate-3-monooxygenase, and the genes of nicotinate degradation in
2012-13 with W. W. Cleland in the Department of Biochemistry, University of Wisconsin-Madison,
and with David Ballou in the Department of Biological Chemistry, University of Michigan.
2007-08 with Tadhg Begley in the Department of Chemical Biology, Cornell University.
D. Fraga., K. Stock*, M. Aryal*, C. Demoll*, L. Fannin*, and M. J. Snider (2019) Bacterial
arginine kinases have a highly skewed distribution within the Proteobacteria. Comparative
Biochemistry and Physiology - Part B 233, 60-71.
K. D. Nakamoto*, S. W. Perkins*, R. G. Campbell*, M. R. Bauerle*, T. G. Gerwig*, S. Gerislioglu,
C. Wesdemiotis, M. A. Anderson, K. A. Hicks and M. J. Snider (2019); Mechanism of
6-hydroxynicotinate 3-monoxygenase, a flavin-dependent decarboxylative hydroxylase
involved in aerobic nicotinic acid degradation; Biochemistry58, 1751-1763.
Katherine A. Hicks, Meigan E. Yuen, Wei Feng Zhen, Tyler J. Gerwig*, Ryan W. Story*,
Megan Kopp, Mark J. Snider (2016) Structural and biochemical characterization of
6-hydroxynicotinic acid 3-monooxygenase, a novel decarboxylative hydroxylase involved
in aerobic nicotinate degradation. Biochemistry 55, 3432-3446.
D. Fraga, M. Aryal*, J. E. Hall*, E. Rae*, and M. Snider (2015) Characterization
of the arginine kinase isoforms in Caenorhabditis elegans. Comparative Physiology and Biochemistry; Part B: Biochemistry & Molecular Biology
Z. H. Harvey* and M. J. Snider (2014) Draft genome of the nicotinate-metablizing
soil bacterium Bacillus niacini (DSM 2923). Genome Announc. 2 (6) e01251-14.
A. Palmer*, B. Begress*, J. Van Houten*, M. J. Snider, and D. Fraga (2013) Characterization
of a putative oomycete taurocyamine kinase: Implications for the evolution of the
phosphagen kinase family. Comparative Physiology and Biochemistry; Part B: Biochemistry
& Molecular Biology, 166; 173-181.
G. K. Schroeder, L. Zhou, M. J. Snider, X. Chen, and R. Wolfenden (2012) Flight of
a cytidine deaminase complex with an imperfect transition state analogue inhibitor:
mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry
J. Bragg, A. Rajkovic*, C. Anderson, R. Curtis, J. V-Houten*, B. Bergres*, C. Naples*,
M. Snider, D. Fraga, and M. Singer (2012) Identification and characterization of an
arginine kinase from Myxococcus xanthus required from fruiting body formation and
cell differentiation; J. Bacteriology 194, 2668-2676.
V. A. Kincaid*, E. D. Sullivan*, R. D. Klein*, J. W. Noel*, R. S. Rowlett, M. J. Snider
(2012) Structure and catalytic mechanism of nicotinate (vitamin B3) degradative enzyme
maleamate amidohydrolase from BrodetellaBronchiseptica RB50; Biochemistry 51, 545-554.